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Can you get metal poisoning from a titanium hip replacement?

Can you get metal poisoning from a titanium hip replacement?

Indeed, the metal alloys used in arthroplasty, including cobalt, chromium, titanium, and aluminum, can release degradation products into the surrounding tissue. These, when circulated systemically, may cause dose-dependent symptoms of metal intoxication [5,6].

What are the symptoms of cobalt toxicity?


  • Cardiomyopathy (a problem where your heart becomes big and floppy and has problems pumping blood)
  • Deafness.
  • Nerve problems.
  • Ringing in the ears (tinnitus)
  • Thickening of the blood.
  • Thyroid problems.
  • Vision problems.

How do you test for cobalt poisoning?

The diagnosis of cobalt toxicity is based on the combination of clinical history and laboratory confirmation. The preferred method of testing is inductively coupled mass spectrometry for metal ion value determination, and the typical patient specimens tested include serum, whole blood, or urine.

How much cobalt is toxic to humans?

The LD 50 value for soluble cobalt salts has been estimated to be between 150 and 500 mg/kg. Thus, for a 100 kg person the LD50 would be about 20 grams. Soluble cobalt(II) salts are “possibly carcinogenic to humans” (IARC Group 2B Agents).

Can you get titanium poisoning?

These titanium ions and particles are systemically deposited and can lead to toxic reactions in other tissues such as yellow nail syndrome. Additionally, implant failure and allergic reactions can occur due to hypersensitivity reactions.

Can your body have a reaction to titanium?

Titanium has also been reported as an allergen in a few studies, causing type I or type IV hypersensitivity reactions [3]. Patients can present with atopic dermatitis, pruritus, edema, urticaria, impaired healing fractures, pain, and necrosis of implants [3].

Can your body reject titanium screws?

The body can reject plates and screws as your body has no material, but titanium as a biomaterial for implants and PEEK is safe and has few complaints so far.

Does titanium dissolve in the body?

The titanium and Co-Cr alloys do not corrode in the body; however, metal ions slowly diffuse through the oxide layer and accumulate in the tissue. Superior fracture and fatigue resistance have made metals the materials of choice for traditional load-bearing applications.